Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00YNY
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| Former ID |
DIB000480
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| Drug Name |
VPC-94075
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| Synonyms |
Sphingosine kinase inhibitor (vascular disease); Sphingosine kinase inhibitor (vascular disease), University of Virgina
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| Drug Type |
Small molecular drug
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| Indication | Vascular disease [ICD-11: BE2Z; ICD-9: 325, 430-459] | Investigative | [1] | |
| Company |
University of Virginia
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| Structure |
 |
Download2D MOL |
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| Formula |
C15H11ClN2OS
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| Canonical SMILES |
C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl
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| InChI |
1S/C15H11ClN2OS/c16-11-3-1-10(2-4-11)14-9-20-15(18-14)17-12-5-7-13(19)8-6-12/h1-9,19H,(H,17,18)
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| InChIKey |
ZFGXZJKLOFCECI-UHFFFAOYSA-N
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| CAS Number |
CAS 312636-16-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
975783, 3370950, 6650876, 8203183, 14776233, 24724614, 26753202, 29215127, 43855033, 47834294, 50076953, 51576088, 57408736, 85789064, 88014805, 92093147, 103738349, 103904804, 104147230, 106816021, 109932051, 118465629, 125335466, 131310014, 134224431, 134964521, 135698127, 139667608, 144048375, 144178932, 162023295, 162163981, 162169536, 162248132, 163125963, 164760274, 166301400, 178102663, 179076036, 184560786, 202561587, 204360307, 206255236, 208013327, 223463584, 226838054, 241070193, 246457339, 250134163, 252156299
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| ChEBI ID |
CHEBI:92375
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sphingosine kinase 1 (SPHK1) | Target Info | Inhibitor | [2] |
| BioCyc | Sphingosine and sphingosine-1-phosphate metabolism | |||
| KEGG Pathway | Sphingolipid metabolism | |||
| Metabolic pathways | ||||
| Calcium signaling pathway | ||||
| Sphingolipid signaling pathway | ||||
| VEGF signaling pathway | ||||
| Fc gamma R-mediated phagocytosis | ||||
| Tuberculosis | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| TNFalpha Signaling Pathway | ||||
| Panther Pathway | Angiogenesis | |||
| VEGF signaling pathway | ||||
| Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | |||
| Beta3 integrin cell surface interactions | ||||
| S1P1 pathway | ||||
| Sphingosine 1-phosphate (S1P) pathway | ||||
| PDGFR-beta signaling pathway | ||||
| Reactome | Sphingolipid de novo biosynthesis | |||
| VEGFR2 mediated cell proliferation | ||||
| WikiPathways | Signal Transduction of S1P Receptor | |||
| Protein folding | ||||
| Sphingolipid Metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6041). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2204). | |||
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