Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00YPW
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| Former ID |
DNC004208
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| Drug Name |
ZAPRINAST
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| Drug Type |
Small molecular drug
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| Structure |
 |
Download2D MOL |
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| Formula |
C13H13N5O2
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| Canonical SMILES |
CCCOC1=CC=CC=C1C2=NC3=NNN=C3C(=O)N2
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| InChI |
1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
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| InChIKey |
REZGGXNDEMKIQB-UHFFFAOYSA-N
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| CAS Number |
CAS 37762-06-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
623910, 4922459, 4991930, 5366120, 7980297, 8149775, 10321616, 11111979, 11111980, 11113810, 11335759, 11360998, 11364159, 11366721, 11369283, 11372065, 11374721, 11377445, 11461970, 11466363, 11467483, 11485049, 11486026, 11489263, 11490748, 11492846, 11495079, 12013177, 14799300, 14872669, 17405794, 24278072, 26604558, 26612231, 26679920, 26747143, 26747144, 26751987, 26759763, 29224759, 46500428, 46514704, 47424342, 47440230, 47499669, 47515302, 47588975, 47720709, 47721704, 47869778
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| ChEBI ID |
CHEBI:92215
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 1 (PDE1) | Target Info | Inhibitor | [1] |
| Phosphodiesterase 4D (PDE4D) | Target Info | Inhibitor | [2] | |
| Phosphodiesterase 5A (PDE5A) | Target Info | Inhibitor | [3] | |
| KEGG Pathway | Purine metabolism | |||
| cAMP signaling pathway | ||||
| Morphine addiction | ||||
| cGMP-PKG signaling pathway | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Pathwhiz Pathway | Purine Metabolism | |||
| Reactome | DARPP-32 events | |||
| G alpha (s) signalling events | ||||
| cGMP effects | ||||
| WikiPathways | G Protein Signaling Pathways | |||
| Myometrial Relaxation and Contraction Pathways | ||||
| TSH signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. J Med Chem. 2005 May 19;48(10):3449-62. | |||
| REF 2 | 8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine: highly potent and selective PDE4 inhibitors. J Med Chem. 2005 Feb 24;48(4):1237-43. | |||
| REF 3 | 4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5. J Med Chem. 2000 Jun 29;43(13):2523-9. | |||
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