Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01CXD
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| Former ID |
DNC008730
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| Drug Name |
9-(Aminomethyl)-9,10-dihydroanthracene
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| Synonyms |
C-(9,10-Dihydro-anthracen-9-yl)-methylamine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H15N
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| Canonical SMILES |
C1C2=CC=CC=C2C(C3=CC=CC=C31)CN
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| InChI |
1S/C15H15N/c16-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)15/h1-8,15H,9-10,16H2
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| InChIKey |
GEICAQNIOJFRQN-UHFFFAOYSA-N
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| CAS Number |
CAS 22136-76-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2A receptor (HTR2A) | Target Info | Inhibitor | [2] |
| Histamine H1 receptor (H1R) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Histamine H1 receptor mediated signaling pathway | |||
| 5HT2 type receptor mediated signaling pathway | ||||
| Reactome | Histamine receptors | |||
| G alpha (q) signalling events | ||||
| Serotonin receptors | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| IL-4 Signaling Pathway | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Serotonin Receptor 2 and STAT3 Signaling | ||||
| Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
| SIDS Susceptibility Pathways | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. | |||
| REF 2 | Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin rec... Bioorg Med Chem Lett. 2001 Feb 26;11(4):563-6. | |||
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