Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01EBJ
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| Former ID |
DIB012167
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| Drug Name |
4991W93
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| Synonyms |
UNII-EP9X802T0C; EP9X802T0C; 171549-56-7; SCHEMBL7838123; SCHEMBL7838126; 2-Oxazolidinone, 4-((3-(trans-3-(dimethylamino)cyclobutyl)-1H-indol-5-yl)methyl)-, (4S)-; LS-192216; 4991-W-93
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| Drug Type |
Small molecular drug
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| Indication | Migraine [ICD-11: 8A80; ICD-10: G43, G43.9; ICD-9: 346] | Discontinued in Phase 2 | [1] | |
| Company |
Glaxo Wellcome plc
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| Structure |
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Download2D MOL |
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| Formula |
C18H23N3O2
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| Canonical SMILES |
CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)CC4COC(=O)N4
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| InChI |
1S/C18H23N3O2/c1-21(2)14-7-12(8-14)16-9-19-17-4-3-11(6-15(16)17)5-13-10-23-18(22)20-13/h3-4,6,9,12-14,19H,5,7-8,10H2,1-2H3,(H,20,22)/t12?,13-,14?/m0/s1
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| InChIKey |
JLDUTSKKXXJGGG-MOKVOYLWSA-N
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| CAS Number |
CAS 171549-56-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sodium channel unspecific (NaC) | Target Info | Modulator | [2] |
| KEGG Pathway | Dopaminergic synapse | |||
| Reactome | Interaction between L1 and Ankyrins | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009029) | |||
| REF 2 | CGRP and its receptors provide new insights into migraine pathophysiology. Nat Rev Neurol. 2010 Oct;6(10):573-82. | |||
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