Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01EBW
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| Drug Name |
Quinoline derivative 12
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| Synonyms |
PMID27724045-Compound-7
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| Drug Type |
Small molecular drug
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| Company |
AstraZeneca
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| Structure |
 |
Download2D MOL |
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| Formula |
C22H28ClN3O3
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| Canonical SMILES |
CC1CCCC(C1)(CNC(=O)C2=C(C=CC3=C2C=CC(=N3)N4CCC(C4)O)Cl)O
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| InChI |
1S/C22H28ClN3O3/c1-14-3-2-9-22(29,11-14)13-24-21(28)20-16-4-7-19(26-10-8-15(27)12-26)25-18(16)6-5-17(20)23/h4-7,14-15,27,29H,2-3,8-13H2,1H3,(H,24,28)/t14-,15+,22-/m0/s1
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| InChIKey |
GTFTZKPCYSYNOU-KIMHZCHSSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | P2X purinoceptor 7 (P2RX7) | Target Info | Antagonist | [1] |
| Voltage-gated potassium channel Kv11.1 (KCNH2) | Target Info | Antagonist | [1] | |
| Target's Patent Info | P2X purinoceptor 7 (P2RX7) | Target's Patent Info | [1] | |
| Voltage-gated potassium channel Kv11.1 (KCNH2) | Target's Patent Info | [1] | ||
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | The NLRP3 inflammasome | |||
| Voltage gated Potassium channels | ||||
| WikiPathways | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | |||
| SIDS Susceptibility Pathways | ||||
| Hematopoietic Stem Cell Differentiation | ||||
| Potassium Channels | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. | |||
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