Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01ESJ
|
|||
| Former ID |
DIB004390
|
|||
| Drug Name |
Luzindole
|
|||
| Synonyms |
Luzindole, Interneuron
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Sleep-wake disorder [ICD-11: 7A00-7B2Z; ICD-10: G47] | Terminated | [1], [2] | |
| Company |
Endo Pharmaceuticals Solutions Inc
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C19H20N2O
|
|||
| Canonical SMILES |
CC(=O)NCCC1=C(NC2=CC=CC=C21)CC3=CC=CC=C3
|
|||
| InChI |
1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)
|
|||
| InChIKey |
WVVXBPKOIZGVNS-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 117946-91-5
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
3153206, 6053777, 10239970, 11113752, 12016180, 14849231, 24896315, 26751931, 29302606, 48029730, 48329130, 50172621, 57339994, 85087357, 85209152, 85787573, 91614231, 103206857, 104415192, 118508042, 126434999, 126591041, 126679033, 129641780, 134223704, 135077966, 135650539, 135697535, 136351165, 137000735, 137242492, 143552894, 162022694, 162092655, 163121981, 164811890, 179149659, 184594679, 204369949, 223454621, 223655888, 230755032, 241181946, 241377507, 249816488, 252160070, 252272687, 252501323
|
|||
| ChEBI ID |
CHEBI:93173
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Melatonin receptor type 1A (MTNR1A) | Target Info | Modulator | [3] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Circadian entrainment | ||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Small Ligand GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1363). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000705) | |||
| REF 3 | Luzindole (N-0774): a novel melatonin receptor antagonist. J Pharmacol Exp Ther. 1988 Sep;246(3):902-10. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.