Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01HJZ
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| Former ID |
DNC010213
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| Drug Name |
N,N-dimethyl-2,2-diphenylethanamine
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| Synonyms |
UNII-MXF0417QII; MXF0417QII; AC1L35TO; CHEMBL10602; diphenylalkylamine (DPA), 4c; BDBM35931; ZINC1249433; 2-Dimethylamino-1,1-diphenylethane; 2-Dimethylamino-1,1-diphenyl-aethan; N,N-Dimethyl-2,2-diphenylethylamine; STL298137; AKOS022110055; MCULE-9768764141; NCGC00246407-01; Ethylamine, N,N-dimethyl-2,2-diphenyl-; Benzeneethanamine, N,N-dimethyl-beta-phenyl-; 2,2-diphenylethyl(dimethyl)amine; 2-Dimethylamino-1,1-diphenyl-aethan [WHO-DD]
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H19N
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| Canonical SMILES |
CN(C)CC(C1=CC=CC=C1)C2=CC=CC=C2
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| InChI |
1S/C16H19N/c1-17(2)13-16(14-9-5-3-6-10-14)15-11-7-4-8-12-15/h3-12,16H,13H2,1-2H3
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| InChIKey |
UAUJDKBNVRSJBD-UHFFFAOYSA-N
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| CAS Number |
CAS 7647-54-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2A receptor (HTR2A) | Target Info | Inhibitor | [1] |
| Histamine H1 receptor (H1R) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Histamine H1 receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| Histamine receptors | ||||
| WikiPathways | Serotonin Receptor 2 and STAT3 Signaling | |||
| Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
| SIDS Susceptibility Pathways | ||||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| IL-4 Signaling Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. | |||
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