Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01HPY
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| Former ID |
DIB001541
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| Drug Name |
Melphalan flufenamide
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| Synonyms |
J-1; Dipeptide-conjugated melphalan prodrug (iv formulation, ovary tumor), Oncopeptides
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| Drug Type |
Small molecular drug
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| Indication | Multiple myeloma [ICD-11: 2A83; ICD-10: C90] | Approved | [1] | |
| Ovarian cancer [ICD-11: 2C73; ICD-10: C56; ICD-9: 183] | Phase 1/2 | [2] | ||
| Plasma cell myeloma [ICD-11: 2A83.1; ICD-10: C90.0] | Phase 1/2 | [3] | ||
| Company |
Oncopeptides AB
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H30Cl2FN3O3
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| Canonical SMILES |
CCOC(=O)C(CC1=CC=C(C=C1)F)NC(=O)C(CC2=CC=C(C=C2)N(CCCl)CCCl)N
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| InChI |
1S/C24H30Cl2FN3O3/c1-2-33-24(32)22(16-18-3-7-19(27)8-4-18)29-23(31)21(28)15-17-5-9-20(10-6-17)30(13-11-25)14-12-26/h3-10,21-22H,2,11-16,28H2,1H3,(H,29,31)/t21-,22-/m0/s1
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| InChIKey |
YQZNKYXGZSVEHI-VXKWHMMOSA-N
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| CAS Number |
CAS 380449-51-4
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human Deoxyribonucleic acid (hDNA) | Target Info | Binder | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021 | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033866) | |||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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