Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01ILN
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| Former ID |
DNC012813
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| Drug Name |
6,7-Diphenyl-pteridine-2,4-diamine
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| Synonyms |
6,7-diphenylpteridine-2,4-diamine; 18181-93-6; 2,4-DIAMINO-6,7-DIPHENYL-PTERIDINE; NSC10922; CHEMBL48296; 2,4-Diamino-6,7-diphenylpteridine; AC1Q4WHR; AC1L5CHW; diphenylpteridine-2,4-diamine; SCHEMBL3746280; diaminopteridine derivative, 24; CTK4D7985; BDBM25101; DTXSID80278987; DDZJPETYMUJLIW-UHFFFAOYSA-N; ZINC1712532; NSC-10922; 2,4-Pteridinediamine,6,7-diphenyl-; 6,7-Diphenyl-2,4-pteridinediamine #; 2,4-Pteridinediamine, 6,7-diphenyl-; ACM18181936; DB-081833
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C18H14N6
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| Canonical SMILES |
C1=CC=C(C=C1)C2=NC3=C(N=C(N=C3N=C2C4=CC=CC=C4)N)N
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| InChI |
1S/C18H14N6/c19-16-15-17(24-18(20)23-16)22-14(12-9-5-2-6-10-12)13(21-15)11-7-3-1-4-8-11/h1-10H,(H4,19,20,22,23,24)
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| InChIKey |
DDZJPETYMUJLIW-UHFFFAOYSA-N
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| CAS Number |
CAS 18181-93-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [1] |
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three ... J Med Chem. 2003 Apr 24;46(9):1726-36. | |||
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