Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01KHH
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| Former ID |
DAP000891
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| Drug Name |
Cyclobenzaprine
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| Synonyms |
Ciclobenzaprina; Cyclobenz; Cyclobenzaprinum; Fexmid; Flexeril; Lisseril; Proeptatriene; Proheptatrien; Proheptatriene; Yurelax; Cyclobenzaprine [INN]; Flexeril hydrochloride; Proeptatriene [Italian]; MK 130; NCI78206; Amrix (TN); Ciclobenzaprina [INN-Spanish]; Cyclobenzaprine (INN); Cyclobenzaprinum [INN-Latin]; Fexmid(TN); Flexeril (TN); MK-130 HCl; Ro 4-1577; Apo-Cyclobenzaprine (TN); N,N-Dimethyl-3-(dibenzo(a,d)cycloheptene-4-ylidene)propylamine; N,N-Dimethyl-5H-dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine; N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-Delta(5,gamma)-propylamine; 1-Propanamine, 3-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-(9CI); 10,11-Dehydroamitriptyline; 3-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine; 3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine; 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine; 5-(3-Dimetilaminopropiliden)-5H-dibenzo-(a,d)-ciclopentene; 5-(3-Dimetilaminopropiliden)-5H-dibenzo-(a,d)-ciclopentene [Italian]; 9715 R.P; 9715 R.P.
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| Drug Type |
Small molecular drug
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| Indication | Depression [ICD-11: 6A70-6A7Z; ICD-9: 311] | Approved | [1], [2] | |
| Therapeutic Class |
Antidepressants
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| Company |
Janssen Research And Development Llc
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H21N
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| Canonical SMILES |
CN(C)CCC=C1C2=CC=CC=C2C=CC3=CC=CC=C31
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| InChI |
1S/C20H21N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-14H,7,15H2,1-2H3
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| InChIKey |
JURKNVYFZMSNLP-UHFFFAOYSA-N
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| CAS Number |
CAS 303-53-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9148, 798360, 4253288, 7407325, 7849637, 8151851, 10320885, 10517820, 11110649, 11110650, 11335222, 11360461, 11364429, 11366991, 11369553, 11372671, 11373782, 11377715, 11446077, 11458991, 11460887, 11461433, 11466473, 11467593, 11485084, 11486165, 11489350, 11491381, 11491977, 11495349, 14872814, 26652854, 29222048, 46508313, 47290965, 47290966, 47290967, 47365012, 47365013, 47440075, 47515151, 47736294, 48110285, 48334305, 49699345, 49961818, 50108641, 50111010, 51092050, 57321502
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| ChEBI ID |
CHEBI:3996
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| ADReCS Drug ID | BADD_D00545 ; BADD_D00546 | |||
| SuperDrug ATC ID |
M03BX08
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| SuperDrug CAS ID |
cas=000303537
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
Show/Hide Hierarchy
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyclobenzaprine can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.482; p = 0.035). | |||
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Studied Microbe: Clostridium sp.
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyclobenzaprine can be metabolized by Clostridium sp. (log2FC = -0.449; p = 0.013). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2 receptor (5HT2R) | Target Info | Antagonist | [4] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7152). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 021777. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Torticollis under Cyclobenzaprine. Pharmacology. 2009 Jul 8;84(2):91-92. | |||
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