Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01KIU
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| Former ID |
DIB000285
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| Drug Name |
PRE-084
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| Synonyms |
Pre-084; 138847-85-5; 2-Morpholinoethyl 1-Phenylcyclohexanecarboxylate; 2-(4-Morpholino)ethyl-1-phenylcyclohexane-1-carboxylate; CHEMBL305881; 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate; Cyclohexanecarboxylic acid, 1-phenyl-, 2-(4-morpholinyl)ethyl ester; Tocris-0589; Lopac-P-2607; AC1L2Q9Z; Lopac0_000927; PRE084; GTPL6678; SCHEMBL5564153; CHEBI:93007; DTXSID40160819; EX-A911; BCP25418; BDBM50039197; ZINC25756875; AKOS027439951; CCG-205008; NCGC00024669-03; NCGC00024669-02; NCGC00024669-01; NCGC00015808-04
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| Drug Type |
Small molecular drug
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| Indication | Aging skin [ICD-11: EE40; ICD-10: L00-L99] | Terminated | [1], [2] | |
| Company |
INSERM
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H27NO3
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| Canonical SMILES |
C1CCC(CC1)(C2=CC=CC=C2)C(=O)OCCN3CCOCC3
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| InChI |
1S/C19H27NO3/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17/h1,3-4,7-8H,2,5-6,9-16H2
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| InChIKey |
RQHKZUBCUZVZEF-UHFFFAOYSA-N
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| CAS Number |
CAS 138847-85-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6443277, 10241571, 11111621, 11113583, 14850372, 26751787, 29305975, 47276721, 50104478, 53790762, 57341759, 75261716, 85788102, 90341330, 103272556, 103946436, 104363572, 124750104, 124881085, 124881086, 124881087, 126435879, 129166397, 135083631, 137146243, 141232620, 162223394, 178103290, 179235769, 231378769
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| ChEBI ID |
CHEBI:93007
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Opioid receptor sigma 1 (OPRS1) | Target Info | Modulator | [3], [4], [5] |
| WikiPathways | miR-targeted genes in squamous cell - TarBase | |||
| miR-targeted genes in lymphocytes - TarBase | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6678). | |||
| REF 2 | Self-administration of cocaine induces dopamine-independent self-administration of sigma agonists. Neuropsychopharmacology. 2013 Mar;38(4):605-15. | |||
| REF 3 | Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice. Pharmacol Rep. 2009 Nov-Dec;61(6):1179-83. | |||
| REF 4 | Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. | |||
| REF 5 | Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6. | |||
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