Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D01KJZ
|
|||
Drug Name |
Pyrazole derivative 4
|
|||
Synonyms |
PMID26161824-Compound-14
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Obesity [ICD-11: 5B81; ICD-10: E66; ICD-9: 278] | Patented | [1] | |
Company |
Mitsubishi Tanabe Pharma Corporation MORITANI, Yasunori IMASHIRO, Ritsuo SATO, Atsush
|
|||
Structure |
Download2D MOL |
|||
Formula |
C25H28Cl2N6O3
|
|||
Canonical SMILES |
CCNC(=O)NCCOC1=C(N(N=C1C(=O)NN2CCCC2)C3=CC=CC=C3Cl)C4=CC=C(C=C4)Cl
|
|||
InChI |
1S/C25H28Cl2N6O3/c1-2-28-25(35)29-13-16-36-23-21(24(34)31-32-14-5-6-15-32)30-33(20-8-4-3-7-19(20)27)22(23)17-9-11-18(26)12-10-17/h3-4,7-12H,2,5-6,13-16H2,1H3,(H,31,34)(H2,28,29,35)
|
|||
InChIKey |
ZDSBVGULFYUNNF-UHFFFAOYSA-N
|
|||
PubChem Compound ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Cannabinoid receptor 1 (CB1) | Target Info | Antagonist | [1] |
Target's Patent Info | Cannabinoid receptor 1 (CB1) | Target's Patent Info | [1] | |
KEGG Pathway | Rap1 signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Retrograde endocannabinoid signaling | ||||
Panther Pathway | Endogenous cannabinoid signaling | |||
Pathway Interaction Database | N-cadherin signaling events | |||
Reactome | Class A/1 (Rhodopsin-like receptors) | |||
G alpha (i) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Small Ligand GPCRs | ||||
BDNF signaling pathway | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
---|---|---|---|---|
REF 1 | A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.