Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01MDT
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| Former ID |
DAP000234
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| Drug Name |
Tizanidine
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| Synonyms |
Sirdalud; Ternelin; Tizanidina; Tizanidinum; Sirdalud (TN); Tizanidina [INN-Spanish]; Tizanidine (INN); Tizanidine [INN:BAN]; Tizanidinum [INN-Latin]; Zanaflex (TN); 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole; 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole; 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine
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| Drug Type |
Small molecular drug
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| Indication | Spasm [ICD-11: MB47.3; ICD-10: R25.2; ICD-9: 338,780] | Approved | [1], [2] | |
| Therapeutic Class |
Analgesics
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| Company |
Elan Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C9H8ClN5S
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| Canonical SMILES |
C1CN=C(N1)NC2=C(C=CC3=NSN=C32)Cl
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| InChI |
1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
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| InChIKey |
XFYDIVBRZNQMJC-UHFFFAOYSA-N
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| CAS Number |
CAS 51322-75-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9655, 4681749, 7980803, 8153374, 15196825, 26754628, 29216212, 29216213, 29224531, 46505373, 48416638, 49890410, 50110110, 50545834, 53787768, 57322804, 61153440, 85172342, 85209776, 90340638, 92308699, 93166738, 93626331, 96025295, 103293859, 104098410, 104178912, 104309371, 117843385, 125324787, 125351824, 126687034, 129683258, 131813309, 134337548, 135001434, 135610138, 137001374, 139157647, 144205429, 160964042, 164823778, 169277583, 170465419, 172848596, 175265727, 176250940, 176484085, 178103881, 179116924
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| ChEBI ID |
CHEBI:63629
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| ADReCS Drug ID | BADD_D02230 ; BADD_D02231 | |||
| SuperDrug ATC ID |
M03BX02
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| SuperDrug CAS ID |
cas=051322759
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor Alpha-2 (ADRA2) | Target Info | Agonist | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7308). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Tizanidine. A review of its pharmacology, clinical efficacy and tolerability in the management of spasticity associated with cerebral and spinal disorders. Drugs. 1997 Mar;53(3):435-52. | |||
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