Drug Information
Drug General Information | Top | |||
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Drug ID |
D01MKM
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Former ID |
DNC013041
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Drug Name |
Tyr-Pro-Hfe-Phe-NH2
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Synonyms |
CHEMBL378466; Tyr-Pro-Hfe-Phe-NH2
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C33H39N5O5
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Canonical SMILES |
C1CC(N(C1)C(=O)C(CC2=CC=C(C=C2)O)N)C(=O)NC(CCC3=CC=CC=C3)C(=O)NC(CC4=CC=CC=C4)C(=O)N
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InChI |
1S/C33H39N5O5/c34-26(20-24-13-16-25(39)17-14-24)33(43)38-19-7-12-29(38)32(42)36-27(18-15-22-8-3-1-4-9-22)31(41)37-28(30(35)40)21-23-10-5-2-6-11-23/h1-6,8-11,13-14,16-17,26-29,39H,7,12,15,18-21,34H2,(H2,35,40)(H,36,42)(H,37,41)/t26-,27-,28-,29-/m0/s1
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InChIKey |
FNDQFOCGSSQYSF-DZUOILHNSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Opioid receptor mu (MOP) | Target Info | Inhibitor | [1] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Estrogen signaling pathway | ||||
Morphine addiction | ||||
NetPath Pathway | TCR Signaling Pathway | |||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Enkephalin release | ||||
Pathway Interaction Database | IL4-mediated signaling events | |||
Reactome | Peptide ligand-binding receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | TCR Signaling Pathway | |||
GPCRs, Class A Rhodopsin-like | ||||
Peptide GPCRs | ||||
Opioid Signalling | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3... Bioorg Med Chem Lett. 2006 Jul 15;16(14):3688-92. |
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