Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01RUN
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| Former ID |
DNC000014
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| Drug Name |
(R)-Rolipram
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| Synonyms |
(R)-(-)-Rolipram; 85416-75-7; (R)-ROLIPRAM; (4R)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE; R-Rolipram; UNII-DPX51KUP08; DPX51KUP08; CHEMBL430893; CHEBI:40133; 1xmy; NCGC00016899-01; CAS-61413-54-5; Tocris-1349; Tocris-0905; Tocris-1350; PubChem18284; 1ro6; 3g4k; 1q9m; AC1L9LJS; Lopac-R-6520; SCHEMBL576805; ZINC4982; KS-00000QDB; MolPort-003-983-801; HMS3267P19; BCP14111
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C16H21NO3
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| Canonical SMILES |
COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3
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| InChI |
1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
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| InChIKey |
HJORMJIFDVBMOB-LBPRGKRZSA-N
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| CAS Number |
CAS 85416-75-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7885372, 7885374, 10300167, 11111747, 11112814, 11113776, 11113777, 11113778, 12016200, 16133703, 36890033, 46392972, 46393090, 46507909, 46507984, 46508075, 50100342, 57404852, 76143228, 85789023, 87235809, 91746538, 93165425, 103332718, 103973669, 104224905, 104638908, 124881346, 124882649, 124882650, 124882651, 124882652, 126616648, 128070171, 134341264, 135266207, 135697605, 137009721, 142521916, 143494407, 144080082, 144220532, 152030706, 152164502, 152238532, 160779380, 160832182, 160965177, 162023069, 162183652
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| ChEBI ID |
CHEBI:40133
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 4 (PDE4) | Target Info | Inhibitor | [1], [2] |
| Phosphodiesterase 4A (PDE4A) | Target Info | Inhibitor | [1] | |
| Phosphodiesterase 4B (PDE4B) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Purine metabolism | |||
| cAMP signaling pathway | ||||
| Morphine addiction | ||||
| NetPath Pathway | IL5 Signaling Pathway | |||
| IL2 Signaling Pathway | ||||
| Reactome | DARPP-32 events | |||
| G alpha (s) signalling events | ||||
| WikiPathways | G Protein Signaling Pathways | |||
| Myometrial Relaxation and Contraction Pathways | ||||
| Nuclear Receptors Meta-Pathway | ||||
| Opioid Signalling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L959-69. | |||
| REF 2 | Phosphodiesterase 4 in osteoblastic osteosarcoma cells as a potential target for growth inhibition. Anticancer Drugs. 2003 Jun;14(5):377-81. | |||
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