Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01RVA
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| Former ID |
DIB017030
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| Drug Name |
ADR-851
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| Synonyms |
Adr 851; 123805-17-4; UNII-303JW6Z3QJ; 303JW6Z3QJ; Adr-851; PCBGZTCWZUGEJX-QRPNPIFTSA-N; AC1L2WPB; SCHEMBL8785455; DTXSID00154097; 4-Amino-5-chloro-N-(2-pyrrolidinylmethyl)-2,3-dihydrobenzofuran-7-carboxamide hcl; KB-289941; 4-amino-5-chloro-N-[[(2S)-pyrrolidin-2-yl]methyl]-2,3-dihydro-1-benzofuran-7-carboxamide hydrochloride; 7-Benzofurancarboxamide, 4-amino-5-chloro-2,3-dihydro-N-(2-pyrrolidinylmethyl)-, monohydrochloride, (S)-; (S)-4-amino-5-chloro-N-(2-pyrrolidinylmethyl)-2,3-dihydrobenzo[b]furan-7-carboxamide hydro
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| Drug Type |
Small molecular drug
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| Indication | Nausea and vomiting [ICD-11: MD90; ICD-10: R11] | Phase 1 | [1] | |
| Company |
Adria Laboratories Inc
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| Structure |
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Download2D MOL |
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| Formula |
C14H19Cl2N3O2
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| Canonical SMILES |
C1CC(NC1)CNC(=O)C2=CC(=C(C3=C2OCC3)N)Cl.Cl
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| InChI |
1S/C14H18ClN3O2.ClH/c15-11-6-10(13-9(12(11)16)3-5-20-13)14(19)18-7-8-2-1-4-17-8;/h6,8,17H,1-5,7,16H2,(H,18,19);1H/t8-;/m0./s1
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| InChIKey |
PCBGZTCWZUGEJX-QRPNPIFTSA-N
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| CAS Number |
CAS 123805-17-4
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 3 receptor (5HT3R) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001323) | |||
| REF 2 | Analgesic effects of S and R isomers of the novel 5-HT3 receptor antagonists ADR-851 and ADR-882 in rats. Eur J Pharmacol. 1991 Oct 29;204(1):117-9. | |||
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