Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01RXM
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| Former ID |
DNC000369
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| Drug Name |
BZ3
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| Synonyms |
5-METHOXYINDOLE; 1006-94-6; 5-Methoxy-1H-indole; 1H-Indole, 5-methoxy-; Femedol; 5-Methoxy indole; Indole, 5-methoxy-; Methoxy-5 indole; Indol-5-yl methyl ether; UNII-DQM3AS43PQ; Methoxy-5 indole [French]; 5-Methoxyindole, 99%; EINECS 213-745-3; DQM3AS43PQ; NSC 521752; CHEMBL280311; DWAQDRSOVMLGRQ-UHFFFAOYSA-N; MFCD00005674; 916979-77-6; BZ3; 5Methoxyindole; 5-methoxyindol; 5-methoxy-indole; 3img; 3imc; PubChem7432; 1,3-dihydro-5-methyl-2H-Indol-2-one; ACMC-1BMAQ; 5-(methyloxy)-1H-indole; AC1Q4F1F; AC1L22NW; SCHEMBL74720; KSC177G3N; WLN: T
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C9H9NO
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| Canonical SMILES |
COC1=CC2=C(C=C1)NC=C2
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| InChI |
1S/C9H9NO/c1-11-8-2-3-9-7(6-8)4-5-10-9/h2-6,10H,1H3
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| InChIKey |
DWAQDRSOVMLGRQ-UHFFFAOYSA-N
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| CAS Number |
CAS 1006-94-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
481053, 590665, 954727, 3133797, 4580631, 8160457, 10502178, 15219189, 16956378, 24896650, 29198240, 29281985, 29621524, 37348378, 37416220, 49747989, 49747990, 49830099, 49984240, 50485552, 53795913, 57328368, 81091036, 85087592, 85248158, 85248164, 87572737, 87617445, 92709947, 93616689, 99214441, 103177917, 104332969, 104669740, 117498597, 117688446, 117715029, 125327801, 125336461, 126544581, 126572620, 126577787, 126593819, 126605827, 126607451, 126614971, 126632357, 126658504, 126668406, 126693609
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Poly [ADP-ribose] polymerase 1 (PARP1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Base excision repair | |||
| NF-kappa B signaling pathway | ||||
| Panther Pathway | FAS signaling pathway | |||
| Pathway Interaction Database | Integrin-linked kinase signaling | |||
| Caspase Cascade in Apoptosis | ||||
| Notch-mediated HES/HEY network | ||||
| Reactome | Dual Incision in GG-NER | |||
| WikiPathways | FAS pathway and Stress induction of HSP regulation | |||
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | ||||
| Nanoparticle triggered regulated necrosis | ||||
| Corticotropin-releasing hormone | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies. Clin Cancer Res. 2003 Jul;9(7):2711-8. | |||
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