Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01TFO
|
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| Former ID |
DNC004033
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| Drug Name |
Z-Ala-Leu-lle-Agly-Ile-Val-OMe
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C36H59N7O9
|
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| Canonical SMILES |
CCC(C)C(C(=O)NNC(=O)NC(C(C)CC)C(=O)NC(C(C)C)C(=O)OC)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)OCC1=CC=CC=C1
|
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| InChI |
1S/C36H59N7O9/c1-11-22(7)28(32(46)39-27(21(5)6)34(48)51-10)41-35(49)43-42-33(47)29(23(8)12-2)40-31(45)26(18-20(3)4)38-30(44)24(9)37-36(50)52-19-25-16-14-13-15-17-25/h13-17,20-24,26-29H,11-12,18-19H2,1-10H3,(H,37,50)(H,38,44)(H,39,46)(H,40,45)(H,42,47)(H2,41,43,49)
|
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| InChIKey |
HGMOIJOFHZHWKH-UHFFFAOYSA-N
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cathepsin B (CTSB) | Target Info | Inhibitor | [1] |
| Cathepsin K (CTSK) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Lysosome | |||
| Antigen processing and presentation | ||||
| Osteoclast differentiation | ||||
| Toll-like receptor signaling pathway | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| IL2 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| RANKL Signaling Pathway | ||||
| Reactome | Collagen degradation | |||
| Trafficking and processing of endosomal TLR | ||||
| Assembly of collagen fibrils and other multimeric structures | ||||
| MHC class II antigen presentation | ||||
| Degradation of the extracellular matrix | ||||
| Activation of Matrix Metalloproteinases | ||||
| WikiPathways | RANKL/RANK Signaling Pathway | |||
| Osteoclast Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. | |||
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