Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01THG
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| Former ID |
DIB021078
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| Drug Name |
trans-2-methylcrotonic acid
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| Synonyms |
tiglic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C5H8O2
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| Canonical SMILES |
CC=C(C)C(=O)O
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| InChI |
1S/C5H8O2/c1-3-4(2)5(6)7/h3H,1-2H3,(H,6,7)/b4-3+
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| InChIKey |
UIERETOOQGIECD-ONEGZZNKSA-N
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| CAS Number |
CAS 80-59-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10477, 74593, 98449, 839849, 3134688, 7849722, 8137936, 8138246, 10241348, 10536312, 14718088, 14718479, 14769262, 24900147, 24901804, 29204622, 29305269, 33623181, 49856779, 50901623, 57341375, 87243834, 87576228, 88809663, 102851512, 103120737, 103239102, 104361424, 107922885, 111677858, 117542518, 126524075, 126656504, 129371913, 134972325, 135071054, 135723590, 137006457, 137026864, 142320368, 162072752, 162162410, 164765602, 178103113, 179316293, 196106822, 198943330, 223681972, 223906689, 225170101
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| ChEBI ID |
CHEBI:9592
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Free fatty acid receptor 2 (FFAR2) | Target Info | Agonist | [2] |
| KEGG Pathway | cAMP signaling pathway | |||
| Reactome | G alpha (q) signalling events | |||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6499). | |||
| REF 2 | Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. J Biol Chem. 2011 Mar 25;286(12):10628-40. | |||
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