Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01UAS
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| Former ID |
DNC006401
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| Drug Name |
6-bromo-3-ethoxycarbonyl-4-quinolone
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| Synonyms |
ethyl 6-bromo-4-hydroxyquinoline-3-carboxylate; 122794-99-4; 79607-23-1; ethyl 6-bromo-4-oxo-1,4-dihydroquinoline-3-carboxylate; 6-Bromo-4-hydroxyquinoline-3-carboxylic acid ethyl ester; Ethyl 6-bromo-4-hydroxy-3-quinolinecarboxylate; ethyl 6-bromo-4-oxo-1H-quinoline-3-carboxylate; 6-bromo-4-hydroxy-quinoline-3-carboxylic acid ethyl ester; CHEMBL205257; 3-QUINOLINECARBOXYLIC ACID, 6-BROMO-4-HYDROXY-, ETHYL ESTER; 6-BROMO-4-HYDROXY-3-QUINOLINECARBOXYLIC ACID ETHYL ESTER; 3-Quinolinecarboxylic acid, 6-bromo-1,4-dihydro-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C12H10BrNO3
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| Canonical SMILES |
CCOC(=O)C1=CNC2=C(C1=O)C=C(C=C2)Br
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| InChI |
1S/C12H10BrNO3/c1-2-17-12(16)9-6-14-10-4-3-7(13)5-8(10)11(9)15/h3-6H,2H2,1H3,(H,14,15)
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| InChIKey |
IVZIOBTVAJBBAS-UHFFFAOYSA-N
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| CAS Number |
CAS 122794-99-4
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [1] |
| GABA(A) receptor alpha-3 (GABRA3) | Target Info | Inhibitor | [1] | |
| GABA(A) receptor beta-2 (GABRB2) | Target Info | Inhibitor | [1] | |
| GABA(A) receptor gamma-2 (GABRG2) | Target Info | Inhibitor | [1] | |
| Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Serotonergic synapse | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. | |||
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