Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01VMZ
|
|||
| Former ID |
DCL001149
|
|||
| Drug Name |
ARI-3037MO
|
|||
| Indication | Cardiovascular disease [ICD-11: BA00-BE2Z; ICD-10: I00-I99, E78; ICD-9: 390-459] | Phase 2 | [1] | |
| Dyslipidemia [ICD-11: 5C80-5C81; ICD-9: 272] | Phase 2 | [2] | ||
| Hypertriglyceridemia [ICD-11: 5C80.1; ICD-10: E78.1, E78.3; ICD-9: 272.1, 427] | Phase 2 | [1] | ||
| Company |
Arisaph Pharmaceuticals
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Diacylglycerol O-acyltransferase 2 (DGAT2) | Target Info | Inhibitor | [3] |
| Hydroxycarboxylic acid receptor 3 (HCAR3) | Target Info | Agonist | [1] | |
| Nicotinic acid receptor (HCAR2) | Target Info | Agonist | [1], [3] | |
| BioCyc | Triacylglycerol biosynthesis | |||
| KEGG Pathway | Glycerolipid metabolism | |||
| Metabolic pathways | ||||
| Fat digestion and absorption | ||||
| Reactome | Acyl chain remodeling of DAG and TAG | |||
| Triglyceride Biosynthesis | ||||
| WikiPathways | Triacylglyceride Synthesis | |||
| Glycerophospholipid biosynthesis | ||||
| Fatty acid, triacylglycerol, and ketone body metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | ClinicalTrials.gov (NCT02250105) Trial of ARI-3037MO to Reduce Triglyceride Levels in Adults With Severe ( 00 mg/dl) Hypertriglyceridemia. U.S. National Institutes of Health. | |||
| REF 3 | 2011 Pipeline of Arisaph Pharmaceuticals. | |||
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