Drug Information
Drug General Information | Top | |||
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Drug ID |
D01XFZ
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Former ID |
DIB001719
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Drug Name |
GPD-1116
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Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Phase 2 | [1] | |
Structure |
Download2D MOL |
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Formula |
C22H16N4O
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Canonical SMILES |
C1=CC=C(C=C1)CC2=C3C(=NN2)C4=C(N=CC=C4)N(C3=O)C5=CC=CC=C5
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InChI |
1S/C22H16N4O/c27-22-19-18(14-15-8-3-1-4-9-15)24-25-20(19)17-12-7-13-23-21(17)26(22)16-10-5-2-6-11-16/h1-13H,14H2,(H,24,25)
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InChIKey |
NOZMPLJNURLIAQ-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Phosphodiesterase 4A (PDE4A) | Target Info | Inhibitor | [1] |
Phosphodiesterase 4B (PDE4B) | Target Info | Inhibitor | [1] | |
Phosphodiesterase 4D (PDE4D) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Purine metabolism | |||
cAMP signaling pathway | ||||
Morphine addiction | ||||
NetPath Pathway | IL5 Signaling Pathway | |||
IL2 Signaling Pathway | ||||
Pathwhiz Pathway | Purine Metabolism | |||
Reactome | DARPP-32 events | |||
G alpha (s) signalling events | ||||
WikiPathways | G Protein Signaling Pathways | |||
Myometrial Relaxation and Contraction Pathways | ||||
Nuclear Receptors Meta-Pathway | ||||
Opioid Signalling | ||||
TSH signaling pathway |
References | Top | |||
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REF 1 | Phosphodiesterase 4 inhibitor GPD-1116 markedly attenuates the development of cigarette smoke-induced emphysema in senescence-accelerated mice P1 s... Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L196-204. |
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