Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01YEN
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| Former ID |
DIB020031
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| Drug Name |
ibotenate
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| Synonyms |
ibotenic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C5H6N2O4
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| Canonical SMILES |
C1=C(ONC1=O)C(C(=O)O)N
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| InChI |
1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
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| InChIKey |
IRJCBFDCFXCWGO-UHFFFAOYSA-N
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| CAS Number |
CAS 2552-55-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
12783, 565789, 5455818, 6240816, 7979560, 8140585, 8151047, 15363851, 17405212, 24277994, 24439578, 26751670, 29204271, 47365404, 47736693, 47736711, 49987522, 50104365, 50104366, 53777757, 56406882, 56463509, 57320830, 79577662, 85209396, 85231090, 90341316, 91704578, 91746333, 92304093, 99300599, 103199832, 103918448, 104297143, 118695783, 119526463, 121361487, 124749888, 124799290, 124880423, 124880424, 125539446, 128209285, 132511300, 134982726, 135652693, 136350327, 137261962, 140862532, 143856972
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| ChEBI ID |
CHEBI:5854
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Metabotropic glutamate receptor 1 (mGluR1) | Target Info | Agonist | [2] |
| Metabotropic glutamate receptor 5 (mGluR5) | Target Info | Agonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | |||
| FoxO signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Long-term potentiation | ||||
| Retrograde endocannabinoid signaling | ||||
| Glutamatergic synapse | ||||
| Long-term depression | ||||
| Estrogen signaling pathway | ||||
| Huntington's disease | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||
| Metabotropic glutamate receptor group III pathway | ||||
| Metabotropic glutamate receptor group I pathway | ||||
| Endogenous cannabinoid signaling | ||||
| Reactome | G alpha (q) signalling events | |||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| WikiPathways | Hypothetical Network for Drug Addiction | |||
| GPCRs, Class C Metabotropic glutamate, pheromone | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1371). | |||
| REF 2 | Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. | |||
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