Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02BXC
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| Former ID |
DNC014634
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| Drug Name |
GNF-PF-117
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| Synonyms |
4-Hydroxy-6-methoxy-2-phenylquinoline; 17282-70-1; GNF-PF-117; 6-methoxy-2-phenylquinolin-4-ol; 6-Methoxy-2-phenyl-4-quinolinol; 6-Methoxy-2-phenyl-1H-quinolin-4-one; CHEMBL14120; 6-Methoxy-2-phenyl-quinolin-4-ol; Maybridge3_005419; AC1L3YAP; Oprea1_238017; SCHEMBL6534282; SCHEMBL10610678; CTK8F6034; CTK7A7980; MolPort-000-677-170; KUC100231N; HMS1446G07; ZINC8649323; 2-Phenyl-4-oxy-6-methoxy-chinolin; KUC100231; BDBM50041130; SBB016283; AKOS009868047; AKOS000273771; MCULE-6727803755; AB10684; CCG-252411; IDI1_016806
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C16H13NO2
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| Canonical SMILES |
COC1=CC2=C(C=C1)NC(=CC2=O)C3=CC=CC=C3
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| InChI |
1S/C16H13NO2/c1-19-12-7-8-14-13(9-12)16(18)10-15(17-14)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
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| InChIKey |
CKFBIYVXNYYXAI-UHFFFAOYSA-N
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| CAS Number |
CAS 57183-50-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tubulin (TUB) | Target Info | Inhibitor | [1] |
| Tubulin beta (TUBB) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Phagosome | |||
| Gap junction | ||||
| Pathogenic Escherichia coli infection | ||||
| NetPath Pathway | FSH Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| EGFR1 Signaling Pathway | ||||
| Panther Pathway | Cytoskeletal regulation by Rho GTPase | |||
| Huntington disease | ||||
| Reactome | Regulation of PLK1 Activity at G2/M Transition | |||
| Loss of Nlp from mitotic centrosomes | ||||
| Recruitment of mitotic centrosome proteins and complexes | ||||
| Loss of proteins required for interphase microtubule organization?from the centrosome | ||||
| Anchoring of the basal body to the plasma membrane | ||||
| WikiPathways | Parkin-Ubiquitin Proteasomal System pathway | |||
| Pathogenic Escherichia coli infection | ||||
| Mitotic G2-G2/M phases | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agent... J Med Chem. 1993 Apr 30;36(9):1146-56. | |||
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