Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02FXS
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| Former ID |
DNC013000
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| Drug Name |
3-carboxy-6-ethyl-4-quinolone
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| Synonyms |
6-ethyl-4-hydroxyquinoline-3-carboxylic acid; 6-Ethyl-4-hydroxy-quinoline-3-carboxylic acid; 103802-41-1; 35128-00-8; 111185-85-4; BAS 02168017; CBMicro_031482; AC1LF0Z6; Cambridge id 6145909; Oprea1_555463; Oprea1_768752; SCHEMBL396402; CHEMBL206122; 3-Quinolinecarboxylic acid, 6-ethyl-1,4-dihydro-4-oxo-; SCHEMBL10032038; CTK6D1895; CTK8F7130; DTXSID70352225; MolPort-000-653-081; MolPort-015-116-184; ZINC3677328; STL229952; 1251AE; SBB015438; AKOS000273237; AKOS009582526; CCG-108136; AB11572; MCULE-1628369792; OR309458
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C12H11NO3
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| Canonical SMILES |
CCC1=CC2=C(C=C1)NC=C(C2=O)C(=O)O
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| InChI |
1S/C12H11NO3/c1-2-7-3-4-10-8(5-7)11(14)9(6-13-10)12(15)16/h3-6H,2H2,1H3,(H,13,14)(H,15,16)
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| InChIKey |
RESVKOSPFKHQBK-UHFFFAOYSA-N
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| CAS Number |
CAS 103802-41-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [1] |
| GABA(A) receptor beta-2 (GABRB2) | Target Info | Inhibitor | [1] | |
| GABA(A) receptor gamma-2 (GABRG2) | Target Info | Inhibitor | [1] | |
| Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Serotonergic synapse | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. | |||
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