Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D02FZD
|
|||
Former ID |
DNC000017
|
|||
Drug Name |
(S)-Rolipram
|
|||
Synonyms |
(S)-(+)-rolipram; 85416-73-5; S-(+)-Rolipram; (S)-ROLIPRAM; S- (+)-Rolipram; UNII-H6G4VMQ24K; H6G4VMQ24K; CHEMBL325795; CHEBI:59540; (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE; (S)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one; (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-pyrrolidin-2-one; S-rolipram; 1oyn; 1xn0; AC1L4KJV; MLS006011228; SCHEMBL5321568; CTK8G3018; DTXSID30234634; HJORMJIFDVBMOB-GFCCVEGCSA-N
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
|||
Formula |
C16H21NO3
|
|||
Canonical SMILES |
COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3
|
|||
InChI |
1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m1/s1
|
|||
InChIKey |
HJORMJIFDVBMOB-GFCCVEGCSA-N
|
|||
CAS Number |
CAS 85416-73-5
|
|||
PubChem Compound ID | ||||
PubChem Substance ID |
7890298, 10253420, 12085819, 16376270, 46234139, 46392830, 46393570, 57348541, 76143230, 81061690, 85197718, 85787603, 91746537, 93581517, 103333097, 103973667, 104253460, 113440732, 124757590, 125164394, 128070170, 135114129, 135697606, 136348713, 136367568, 136946610, 137133766, 142521914, 152137936, 152198696, 162023071, 162037764, 162201769, 163137913, 176484875, 198938016, 198939252, 210279538, 210281861, 223516226, 223705241, 231162484, 241182352, 241375374, 252160141, 252220216
|
|||
ChEBI ID |
CHEBI:59540
|
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Phosphodiesterase 4 (PDE4) | Target Info | Inhibitor | [1], [2] |
Phosphodiesterase 4A (PDE4A) | Target Info | Inhibitor | [1] | |
Phosphodiesterase 4B (PDE4B) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Purine metabolism | |||
cAMP signaling pathway | ||||
Morphine addiction | ||||
NetPath Pathway | IL5 Signaling Pathway | |||
IL2 Signaling Pathway | ||||
Reactome | DARPP-32 events | |||
G alpha (s) signalling events | ||||
WikiPathways | G Protein Signaling Pathways | |||
Myometrial Relaxation and Contraction Pathways | ||||
Nuclear Receptors Meta-Pathway | ||||
Opioid Signalling |
References | Top | |||
---|---|---|---|---|
REF 1 | PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L959-69. | |||
REF 2 | Phosphodiesterase 4 in osteoblastic osteosarcoma cells as a potential target for growth inhibition. Anticancer Drugs. 2003 Jun;14(5):377-81. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.