Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02GMT
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| Former ID |
DIB011935
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| Drug Name |
Org-7797
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| Synonyms |
org7797; 80177-51-1; Org 7797; SCHEMBL11227348; EINECS 279-413-5; AKOS030532756; (3,16alpha-Dihydroxyestra-1,3,5(10)-trien-17beta-yl)(methyl)ammonium hydrogen maleate; Estra-1,3,5(10)-triene-3,16-diol, 17-(methylamino)-, (16alpha,17beta)-, (Z)-2-butenedioate (1:1) (salt)
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| Drug Type |
Small molecular drug
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| Indication | Cardiac arrhythmias [ICD-11: BC9Z; ICD-9: 427] | Discontinued in Phase 2 | [1] | |
| Company |
Organon BioSciences
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| Structure |
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Download2D MOL |
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| Formula |
C23H31NO6
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| Canonical SMILES |
CC12CCC3C(C1CC(C2NC)O)CCC4=C3C=CC(=C4)O.C(=CC(=O)O)C(=O)O
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| InChI |
1S/C19H27NO2.C4H4O4/c1-19-8-7-14-13-6-4-12(21)9-11(13)3-5-15(14)16(19)10-17(22)18(19)20-2;5-3(6)1-2-4(7)8/h4,6,9,14-18,20-22H,3,5,7-8,10H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15-,16+,17-,18+,19+;/m1./s1
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| InChIKey |
UDCGSEPMGRJOAG-IQQQYFTASA-N
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| CAS Number |
CAS 80177-51-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sodium channel unspecific (NaC) | Target Info | Modulator | [2] |
| KEGG Pathway | Dopaminergic synapse | |||
| Reactome | Interaction between L1 and Ankyrins | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000279) | |||
| REF 2 | Electrophysiologic effects of Org 7797, a new steroidal antiarrhythmic agent: comparison with class 1a, 1b, and 1c drugs. J Cardiovasc Pharmacol. 1989 Aug;14(2):205-12. | |||
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