Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02HUB
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| Former ID |
DIB011230
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| Drug Name |
Nestorone
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| Synonyms |
Nestorone; Nestorone MDTS; Nestorone metered dose transdermal system; Nestorone transdermal spray, Acrux; ST-1435; Nestorone transdermal spray, Population Council/Acrux
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| Drug Type |
Small molecular drug
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| Indication | Endometriosis [ICD-11: GA10; ICD-10: N80, N80.9; ICD-9: 617] | Phase 3 | [1] | |
| Company |
Population Council; Population Council Center for Biomedical Research
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| Structure |
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Download2D MOL |
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| Formula |
C23H30O4
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| Canonical SMILES |
CC(=O)C1(C(=C)CC2C1(CCC3C2CCC4=CC(=O)CCC34)C)OC(=O)C
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| InChI |
1S/C23H30O4/c1-13-11-21-20-7-5-16-12-17(26)6-8-18(16)19(20)9-10-22(21,4)23(13,14(2)24)27-15(3)25/h12,18-21H,1,5-11H2,2-4H3/t18-,19+,20+,21-,22-,23-/m0/s1
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| InChIKey |
CKFBRGLGTWAVLG-GOMYTPFNSA-N
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| CAS Number |
7759-35-5
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Progesterone receptor (PGR) | Target Info | Agonist | [2] |
| KEGG Pathway | Oocyte meiosis | |||
| Progesterone-mediated oocyte maturation | ||||
| Pathway Interaction Database | Cellular roles of Anthrax toxin | |||
| Reactome | Nuclear signaling by ERBB4 | |||
| Nuclear Receptor transcription pathway | ||||
| WikiPathways | Ovarian Infertility Genes | |||
| Signaling by ERBB4 | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00455156) Study of the Safety, Efficacy and Cycle Control of a Contraceptive Vaginal Ring. U.S. National Institutes of Health. | |||
| REF 2 | Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis. J Neuroimmunol. 2014 Nov 15;276(1-2):89-97. | |||
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