Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02LWU
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| Former ID |
DAP001549
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| Drug Name |
Pralatrexate
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| Synonyms |
Folotyn (TN)
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| Drug Type |
Small molecular drug
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| Indication | Breast cancer [ICD-11: 2C60-2C65] | Approved | [1], [2], [3] | |
| Peripheral T-cell lymphoma [ICD-11: 2A90.C; ICD-10: C84.4] | Approved | [1], [2], [3] | ||
| Company |
Allos Therapeutics
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| Structure |
 |
Download2D MOL |
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| Formula |
C23H23N7O5
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| Canonical SMILES |
C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
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| InChI |
1S/C23H23N7O5/c1-2-3-14(10-15-11-26-20-18(27-15)19(24)29-23(25)30-20)12-4-6-13(7-5-12)21(33)28-16(22(34)35)8-9-17(31)32/h1,4-7,11,14,16H,3,8-10H2,(H,28,33)(H,31,32)(H,34,35)(H4,24,25,26,29,30)/t14?,16-/m0/s1
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| InChIKey |
OGSBUKJUDHAQEA-WMCAAGNKSA-N
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| CAS Number |
CAS 146464-95-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10249810, 14761163, 14907808, 46225076, 47207252, 57346701, 76049103, 99437279, 103771482, 104418267, 124950714, 126666101, 131408688, 134223179, 135692165, 136367814, 137248707, 141792755, 144206459, 144236486, 152106310, 152258219, 152344466, 160646081, 160647055, 164044033, 164232763, 164764489, 175427094, 175437712, 176484650, 178103446, 180191813, 184527271, 186014781, 198993109, 223392464, 223659651, 223702389, 225255488, 226410872, 240035409, 241036657, 243124404, 249868098, 252069088, 252214139, 252473148
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| ChEBI ID |
CHEBI:71223
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| ADReCS Drug ID | BADD_D01814 | |||
| SuperDrug ATC ID |
L01BA05
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [2] |
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6840). | |||
| REF 2 | Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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