Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02LZB
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| Former ID |
DNAP001634
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| Drug Name |
Demecolcine
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| Synonyms |
colcemid; 1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one; demecolcine,colcemid, n-deacetyl-n-methylcolchicine, n-methyl-n-desacetylcolchicine; Demicolcine; NSC3096; 1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one; NCGC00166035-01; AC1L1EKK; MolMap_000011; SCHEMBL8160; AC1Q698E; CHEMBL433632; CTK8E8505; MolPort-003-846-192; 6,7-Dihydro-1,2,3,10-Tetramethoxy-7-(Methylamino) Benzo (alpha) Heptalen-9(5H)-one; HMS3374M04; HSCI1_000384; BBL027927; STL377913; CD0013
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Approved | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C21H25NO5
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| Canonical SMILES |
CNC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
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| InChI |
1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1
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| InChIKey |
NNJPGOLRFBJNIW-HNNXBMFYSA-N
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| CAS Number |
CAS 477-30-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
13427, 638145, 4425078, 8151828, 11404353, 26758484, 29217793, 29221987, 47662411, 57321486, 57559694, 77082638, 85085168, 85787231, 91612090, 103244665, 103821003, 104301745, 117584383, 119511323, 125433551, 126688762, 128727291, 134973666, 137243776, 142893148, 163123417, 163688352, 164788291, 165745041, 173901297, 178127404, 179148472, 184014795, 184545645, 204376684, 211535218, 215743624, 223670947, 226399419
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| ChEBI ID |
CHEBI:4393
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| SuperDrug ATC ID |
L01CC01
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Microtubule-associated protein (MAP) | Target Info | Modulator | [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81. | |||
| REF 3 | The role of weeds as sources of pharmaceuticals. J Ethnopharmacol. 2004 Jun;92(2-3):163-6. | |||
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