Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02NIP
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| Former ID |
DIB014171
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| Drug Name |
ITASETRON
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| Synonyms |
DAU6215CL; DAU-6215; Itasetron < Rec INN; U-98079A; N-(endo-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-2,3-dihydro-1H-benzimidazole-1-carboxamide; 2-Oxo-N-(1alphaH,5alphaH-tropan-3alpha-yl)-1-benzimidazoline-1-carboxamide
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| Drug Type |
Small molecular drug
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| Indication | Nausea [ICD-11: MD90; ICD-10: R11] | Phase 1 | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C16H20N4O2
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| Canonical SMILES |
CN1C2CCC1CC(C2)NC(=O)N3C4=CC=CC=C4NC3=O
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| InChI |
1S/C16H20N4O2/c1-19-11-6-7-12(19)9-10(8-11)17-15(21)20-14-5-3-2-4-13(14)18-16(20)22/h2-5,10-12H,6-9H2,1H3,(H,17,21)(H,18,22)/t10?,11-,12+
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| InChIKey |
RWXRJSRJIITQAK-YOGCLGLASA-N
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| CAS Number |
CAS 123258-84-4
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:140079
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 3 receptor (5HT3R) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT02259985) Effects of Food on the Bioavailability and Pharmacokinetic Profile of Itasetron After a Single Oral Dose in Healthy Male Subjects. U.S. National Institutes of Health. | |||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | |||
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