Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02NZE
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| Former ID |
DIB019554
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| Drug Name |
PMID20483621C5m
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| Synonyms |
GTPL8206; BDBM50321053
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C31H33ClF3N5O
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| Canonical SMILES |
C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)C4=CC5=C(NCCN5CC6=C(C=CC(=C6)Cl)C(F)(F)F)N=C4
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| InChI |
1S/C31H33ClF3N5O/c32-25-7-8-27(31(33,34)35)24(17-25)20-40-16-11-36-29-28(40)18-23(19-37-29)21-3-5-22(6-4-21)30(41)39-14-9-26(10-15-39)38-12-1-2-13-38/h3-8,17-19,26H,1-2,9-16,20H2,(H,36,37)
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| InChIKey |
JVVGHVJDZJSKRA-UHFFFAOYSA-N
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| CAS Number |
CAS 957194-90-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | ALK tyrosine kinase receptor (ALK) | Target Info | Inhibitor | [1] |
| BMP-2-inducible protein kinase (BMP2K) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Non-small cell lung cancer | |||
| WikiPathways | Differentiation Pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase. Bioorg Med Chem. 2010 Jun 15;18(12):4351-62. | |||
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