Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02OTH
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| Former ID |
DIB009137
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| Drug Name |
FR-115427
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| Synonyms |
FR-115427; 1-Methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline; (+)-1,2,3,4-Tetrahydro-1-methyl-1-phenylisoquinoline hydrochloride; Isoquinoline, 1,2,3,4-tetrahydro-1-methyl-1-phenyl-, hydrochloride, (+)-; FR115427; 126114-66-7; SCHEMBL6021932; AC1L2Y54; LS-172648; FR 115427; 1-methyl-1-phenyl-3,4-dihydro-2H-isoquinoline hydrochloride; (+)-1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
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| Drug Type |
Small molecular drug
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| Indication | Cerebrovascular ischaemia [ICD-11: 8B1Z; ICD-10: I67.8; ICD-9: 434.91] | Terminated | [1] | |
| Company |
Fujisawa Pharmaceutical Co Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C16H18ClN
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| Canonical SMILES |
CC1(C2=CC=CC=C2CCN1)C3=CC=CC=C3.Cl
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| InChI |
1S/C16H17N.ClH/c1-16(14-8-3-2-4-9-14)15-10-6-5-7-13(15)11-12-17-16;/h2-10,17H,11-12H2,1H3;1H
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| InChIKey |
LUSUZDOXGNAITA-UHFFFAOYSA-N
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| CAS Number |
CAS 126114-66-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | N-methyl-D-aspartate receptor (NMDAR) | Target Info | Modulator | [2] |
| References | Top | |||
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| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009401) | |||
| REF 2 | Non-competitive NMDA antagonists, FR115427 and MK801, enhance neuronal survival in primary culture. Neurosci Lett. 1995 Feb 9;185(2):107-10. | |||
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