Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02RAN
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| Former ID |
DNC000789
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| Drug Name |
Imetit
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| Synonyms |
imetit; S-(2-(4-Imidazolyl)ethyl)isothiourea; 102203-18-9; UNII-677MJ4VPZC; 2-(1H-Imidazol-4-yl)ethyl carbamimidothioate; 677MJ4VPZC; CHEMBL19439; CHEBI:64156; 2-(1h-imidazol-5-yl)ethyl carbamimidothioate; Carbamimidothioic acid, 2-(1H-imidazol-4-yl)ethyl ester; 2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide; C6H10N4S; Carbamimidothioic acid,2-(1H-imidazol-5-yl)ethyl ester; S-[2-(4-imidazolyl)ethyl]isothiourea; Tocris-0729; Lopac-I-135; AC1Q7DRW; ACMC-20m57g; AC1L1GI2; Lopac0_000645; SCHEMBL114670; GTPL1250; DTXSID8043737
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C6H10N4S
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| Canonical SMILES |
C1=C(NC=N1)CCSC(=N)N
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| InChI |
1S/C6H10N4S/c7-6(8)11-2-1-5-3-9-4-10-5/h3-4H,1-2H2,(H3,7,8)(H,9,10)
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| InChIKey |
PEHSVUKQDJULKE-UHFFFAOYSA-N
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| CAS Number |
CAS 102203-18-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4725777, 7979594, 11111301, 11113668, 14772577, 15321889, 17182199, 26751853, 29222815, 47365323, 49846725, 50064072, 50104554, 50378622, 57309872, 57321944, 85209111, 90341548, 96024152, 103103017, 103184402, 104304247, 117401315, 124749884, 124880387, 124880388, 124880389, 128903678, 132556095, 134340115, 135072524, 135610596, 135650381, 136351577, 137132880, 138330873, 142231010, 142667100, 144235392, 162354693, 162769104, 179235712, 198952140, 226487103
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| ChEBI ID |
CHEBI:64156
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H3 receptor (H3R) | Target Info | Agonist | [2] |
| Histamine H4 receptor (H4R) | Target Info | Agonist | [3], [4] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine Transport | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1250). | |||
| REF 2 | The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. | |||
| REF 3 | Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. J Neurophysiol. 2006 Apr;95(4):2492-500. | |||
| REF 4 | Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br J Pharmacol. 2004 May;142(1):161-71. | |||
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