Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02VKC
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| Former ID |
DNC003508
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| Drug Name |
NBQX
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| Synonyms |
nbqx; 118876-58-7; FG 9202; 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline; 6-Nitro-7-sulfamoylbenzo(f)quinoxaline-2,3-dione; CHEMBL222519; CHEBI:31073; SBB066176; 6-nitro-2,3-dioxo-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide; 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxobenzo(f)quinoxaline-8-sulfonamide; 6-Nitro-7-sulphamoylbenzo[f]quinoxaline-2,3-dione; 6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-Dione; 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline
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| Drug Type |
Small molecular drug
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| Indication | Neurological disorder [ICD-11: 6B60] | Phase 1 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H8N4O6S
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| Canonical SMILES |
C1=CC2=C3C(=CC(=C2C(=C1)S(=O)(=O)N)[N+](=O)[O-])NC(=O)C(=O)N3
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| InChI |
1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22)
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| InChIKey |
UQNAFPHGVPVTAL-UHFFFAOYSA-N
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| CAS Number |
CAS 118876-58-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
586260, 3153212, 4634329, 7980097, 9251954, 11113470, 14777739, 15397501, 26751693, 26759268, 34646396, 47216894, 47349363, 47662425, 50066260, 50251812, 53789223, 57356141, 72276108, 85245460, 85787793, 85788629, 91615359, 103509729, 109613894, 111881947, 118313821, 118508041, 125338989, 129406224, 134340713, 135061214, 135698079, 137009451, 137014386, 141003654, 142845642, 143245648, 143438594, 143552884, 152035117, 162022609, 162222865, 163687583, 164805409, 170539125, 178101081, 179293796, 223441583, 224912602
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| ChEBI ID |
CHEBI:31073
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4264). | |||
| REF 2 | Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil r... J Med Chem. 2007 Apr 5;50(7):1558-70. | |||
| REF 3 | Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Syn... J Med Chem. 2006 Oct 5;49(20):6015-26. | |||
| REF 4 | 4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with... Bioorg Med Chem Lett. 2000 May 15;10(10):1133-7. | |||
| REF 5 | Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,... J Med Chem. 2001 Sep 13;44(19):3157-65. | |||
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