Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02WIW
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| Former ID |
DAP001068
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| Drug Name |
Dexbrompheniramine
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| Synonyms |
Dexbromfeniramina; Dexbrompheniraminum; Ilvin; Parabromodylamine; D-Brompheniramine; Dexbromfeniramina [INN-Spanish]; Dexbrompheniramine [INN:BAN]; Dexbrompheniraminum [INN-Latin]; N,N-Dimethyl-(3-(4-bromphenyl)-3-(2-pyridyl)propyl)amin; (3-p-Bromphenyl-3-pyrid-2'-ylpropyl)dimethylamin; (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine; (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine; (S)-(+)-brompheniramine; (S)-brompheniramine
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| Drug Type |
Small molecular drug
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| Indication | Hay fever [ICD-11: CA08.00; ICD-10: J30.1] | Approved | [1], [2], [3] | |
| Therapeutic Class |
Antihistamines
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| Company |
Schering Corp Sub Schering Plough Corp
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| Structure |
 |
Download2D MOL |
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| Formula |
C16H19BrN2
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| Canonical SMILES |
CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2
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| InChI |
1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1
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| InChIKey |
ZDIGNSYAACHWNL-HNNXBMFYSA-N
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| CAS Number |
CAS 132-21-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
8162708, 29216402, 29284761, 46505186, 47424231, 47499547, 47869645, 47943752, 48243357, 48415865, 50064340, 50110984, 50892258, 57329587, 90341837, 92741717, 104341228, 117389139, 123092153, 124749558, 135051501, 136061981, 137002508, 141867227, 152109073, 160963751, 175267559, 175270118, 179296079, 184545934, 184654397, 210024055, 223365923, 226416446, 249924738, 252346858, 252347937
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| ChEBI ID |
CHEBI:59269
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| SuperDrug ATC ID |
R06AB06
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| SuperDrug CAS ID |
cas=000132218
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H1 receptor (H1R) | Target Info | Antagonist | [4] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | Histamine H1 receptor mediated signaling pathway | |||
| Reactome | Histamine receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| IL-4 Signaling Pathway | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7588). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 089116. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 4 | H2 histaminergic control of inhibition of eating induced by intragastric NaCl in rats. Physiol Behav. 1998 Aug;65(1):105-13. | |||
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