Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03CGQ
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| Former ID |
DIB004142
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| Drug Name |
AG-013958
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| Synonyms |
AG-13958
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| Indication | Age-related macular degeneration [ICD-11: 9B75.0; ICD-9: 362.5] | Phase 1/2 | [1] | |
| Company |
Pfizer Inc
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| Structure |
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Download2D MOL |
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| Formula |
C26H22FN7O
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| Canonical SMILES |
CC1=NN(C(=C1)C(=O)NC2=C(C=CC(=C2)NC3=CC4=C(C=C3)C(=NN4)C=CC5=CC=CC=N5)F)C
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| InChI |
1S/C26H22FN7O/c1-16-13-25(34(2)33-16)26(35)30-24-15-19(7-10-21(24)27)29-18-6-9-20-22(31-32-23(20)14-18)11-8-17-5-3-4-12-28-17/h3-15,29H,1-2H3,(H,30,35)(H,31,32)/b11-8+
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| InChIKey |
JXSVVZKPEDIRTN-DHZHZOJOSA-N
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| CAS Number |
CAS 319460-94-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Vascular endothelial growth factor receptor (VEGFR) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00090532) A Study Of The Safety And Efficacy Of AG-013,958 In Subjects With Subfoveal Choroidal Neovascularization Associated With Age-Related Macular Degeneration. U.S. National Institutes of Health. | |||
| REF 2 | Receptor Tyrosine Kinase Inhibitors AG013764 and AG013711 Reduce Choroidal Neovascularization in Rat Eye. Exp Eye Res. 2007 May; 84(5): 922-933. | |||
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