Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03LDH
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| Former ID |
DNC004833
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| Drug Name |
1-Benzyl-4-chroman-2-ylmethyl-piperazine
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| Synonyms |
CHEMBL179648; 1-Benzyl-4-chroman-2-ylmethyl-piperazine; SCHEMBL8031431; AJZBPCAHQHCXMX-UHFFFAOYSA-N; BDBM50159018; 1-[(chroman-2-yl)methyl]-4-benzylpiperazine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C21H26N2O
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| Canonical SMILES |
C1CC2=CC=CC=C2OC1CN3CCN(CC3)CC4=CC=CC=C4
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| InChI |
1S/C21H26N2O/c1-2-6-18(7-3-1)16-22-12-14-23(15-13-22)17-20-11-10-19-8-4-5-9-21(19)24-20/h1-9,20H,10-17H2
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| InChIKey |
AJZBPCAHQHCXMX-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1A receptor (HTR1A) | Target Info | Inhibitor | [1] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| 5HT1 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
| SIDS Susceptibility Pathways | ||||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. J Med Chem. 2005 Jan 13;48(1):266-73. | |||
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