Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03NUN
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| Former ID |
DNC014488
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| Drug Name |
(+/-)-threo-Methylphenidate amide
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| Synonyms |
UNII-HS1P4T2LCV; HS1P4T2LCV; CHEMBL1253490; 160707-37-9; 50288-62-5; SCHEMBL14453323; ZINC5934431; BDBM50327105; D-threo-; A-Phenyl-2-piperidineacetamide; AJ-55250; AR,2R)-; FT-0673813; FT-0673810; (D,L)-threo-; (alphaR,2R)-alpha-Phenyl-2-piperidineacetamide; AR,2R)-rel-; (D,L)-threo-alpha-Phenyl-2-piperidineacetamide; alpha-Phenyl-2-piperidineacetamide, threo-(+)-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C13H18N2O
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| Canonical SMILES |
C1CCNC(C1)C(C2=CC=CC=C2)C(=O)N
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| InChI |
1S/C13H18N2O/c14-13(16)12(10-6-2-1-3-7-10)11-8-4-5-9-15-11/h1-3,6-7,11-12,15H,4-5,8-9H2,(H2,14,16)/t11-,12-/m1/s1
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| InChIKey |
LJLMNWPXAYKPGV-VXGBXAGGSA-N
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| CAS Number |
CAS 160707-37-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dopamine transporter (DAT) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Dopaminergic synapse | |||
| Parkinson's disease | ||||
| Cocaine addiction | ||||
| Amphetamine addiction | ||||
| Alcoholism | ||||
| Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
| Parkinson disease | ||||
| Dopamine receptor mediated signaling pathway | ||||
| Pathway Interaction Database | Alpha-synuclein signaling | |||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
| WikiPathways | Monoamine Transport | |||
| NRF2 pathway | ||||
| Dopaminergic Neurogenesis | ||||
| Parkinsons Disease Pathway | ||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
| Neurotransmitter Clearance In The Synaptic Cleft | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. | |||
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