Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03OFO
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| Former ID |
DNC012138
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| Drug Name |
L-768673
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| Synonyms |
L-768673; CHEMBL16900; SCHEMBL7207125; BDBM50061209; LS-28521; l-768,673
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| Drug Type |
Small molecular drug
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| Structure |
 |
Download2D MOL |
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| Formula |
C27H18F9N3O2
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| Canonical SMILES |
C1=CC=C(C=C1)C2=NC(C(=O)N(C3=CC=CC=C32)CC(F)(F)F)NC(=O)CC4=C(C=C(C=C4)C(F)(F)F)C(F)(F)F
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| InChI |
1S/C27H18F9N3O2/c28-25(29,30)14-39-20-9-5-4-8-18(20)22(15-6-2-1-3-7-15)38-23(24(39)41)37-21(40)12-16-10-11-17(26(31,32)33)13-19(16)27(34,35)36/h1-11,13,23H,12,14H2,(H,37,40)/t23-/m1/s1
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| InChIKey |
VVCYJFVTVHMTBV-HSZRJFAPSA-N
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| CAS Number |
CAS 177954-68-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated potassium channel Kv7.1 (KCNQ1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Adrenergic signaling in cardiomyocytes | |||
| Cholinergic synapse | ||||
| Gastric acid secretion | ||||
| Pancreatic secretion | ||||
| Protein digestion and absorption | ||||
| Vibrio cholerae infection | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Voltage gated Potassium channels | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Potassium Channels | ||||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| TarBasePathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(... J Med Chem. 1997 Nov 21;40(24):3865-8. | |||
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