Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03QGB
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| Former ID |
DNC002348
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| Drug Name |
JNJ-5207852
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| Synonyms |
398473-34-2; JNJ-5207852; UNII-4I9OVB1G7D; JNJ 5207852; 1-[4-(3-piperidinopropoxy)benzyl]piperidine; 4I9OVB1G7D; CHEMBL129542; JNJ 5207852 dihydrochloride; 1-[3-[4-(piperidin-1-ylmethyl)phenoxy]propyl]piperidine; Piperidine, 1-(3-(4-(1-piperidinylmethyl)phenoxy)propyl)-; 1-(3-(4-((Piperidin-1-yl)methyl)phenoxy)propyl)piperidine; 1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piperidine; Piperidine, 1-[3-[4-(1-piperidinylmethyl)phenoxy]propyl]-; 1-(3-{4-[(piperidin-1-yl)methyl]phenoxy}propyl)piperidine; AC1MCCJO
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| Drug Type |
Small molecular drug
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| Indication | Narcolepsy [ICD-11: 7A20; ICD-10: G47.4; ICD-9: 347] | Investigative | [1] | |
| Company |
Johnson & Johnson
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H32N2O
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| Canonical SMILES |
C1CCN(CC1)CCCOC2=CC=C(C=C2)CN3CCCCC3
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| InChI |
1S/C20H32N2O/c1-3-12-21(13-4-1)16-7-17-23-20-10-8-19(9-11-20)18-22-14-5-2-6-15-22/h8-11H,1-7,12-18H2
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| InChIKey |
PTKHFRNHJULJKT-UHFFFAOYSA-N
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| CAS Number |
CAS 398473-34-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3196602, 5392837, 8302527, 14821295, 25782704, 39181268, 49665761, 78415116, 85227379, 88728348, 103361523, 103856695, 104045710, 109623889, 111376115, 125163397, 125444230, 135649651, 137128903, 139563581, 162507776, 172113486, 172919121, 179524509, 187581008, 198982782, 224053991, 229581697, 247251069
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H3 receptor (H3R) | Target Info | Antagonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine Transport | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1256). | |||
| REF 2 | The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. | |||
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