Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03QWT
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| Former ID |
DCL000778
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| Drug Name |
Doripenem
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| Synonyms |
Doribax; S 4661; S-4661; Doripenem (USAN/INN); (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-[(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Urinary tract infection [ICD-11: GC08; ICD-10: N39, N39.0; ICD-9: 599] | Approved | [1], [2] | |
| Gram-positive bacterial infection [ICD-11: 1B74-1G40] | Phase 3 | [3] | ||
| Company |
Shionogi; penisula
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| Structure |
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Download2D MOL |
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| Formula |
C15H24N4O6S2
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| Canonical SMILES |
CC1C2C(C(=O)N2C(=C1SC3CC(NC3)CNS(=O)(=O)N)C(=O)O)C(C)O
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| InChI |
1S/C15H24N4O6S2/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25)/t6-,7-,8+,9+,10-,11-/m1/s1
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| InChIKey |
AVAACINZEOAHHE-VFZPANTDSA-N
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| CAS Number |
CAS 148016-81-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
8195661, 14782518, 14904822, 17397979, 43129277, 50112763, 57319033, 78931074, 99299161, 103596434, 104354952, 118047125, 126665586, 134339262, 135030316, 136367963, 137103545, 140972593, 144115919, 144206061, 152057781, 152344294, 164824831, 170465085, 174527594, 175266776, 175437740, 179117027, 184547713, 210279313, 210281636, 223556613, 223659794, 226423250, 241037251, 242439235, 249358056, 249583208, 249822520, 251963975, 251970995, 252215304, 252348782
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| ChEBI ID |
CHEBI:135928
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| ADReCS Drug ID | BADD_D00710 | |||
| SuperDrug ATC ID |
J01DH04
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial Dihydropteroate synthetase (Bact folP) | Target Info | Inhibitor | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9. | |||
| REF 2 | 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. | |||
| REF 3 | Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. | |||
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