Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D03SAM
|
|||
Former ID |
DNC000012
|
|||
Drug Name |
(R)-alpha-methylhistamine
|
|||
Synonyms |
(R)-alpha-Methylhistamine; CHEBI:73337; r-alpha-methylhistamine; (R)alpha-Me-histamine; CHEMBL268229; (R)-(-)-alpha-methylhistamine; (2R)-1-(1H-imidazol-4-yl)propan-2-amine; 75614-87-8; 1H-Imidazole-4-ethanamine, alpha-methyl-, (alphaR)-; (R)-(-)-4-(2-aminopropyl)imidazole; (2R)-1-(3H-imidazol-4-yl)propan-2-amine; (2R)-1-(1H-imidazol-5-yl)propan-2-amine; Alpha-Methylhistamine-R; C6H11N3; [3H]-R-alpha-Methylhistamine; (R)-[3H]alpha-methylhistamine; [3H](R)-alpha-methylhistamine
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
Structure |
Download2D MOL |
|||
Formula |
C6H11N3
|
|||
Canonical SMILES |
CC(CC1=CN=CN1)N
|
|||
InChI |
1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m1/s1
|
|||
InChIKey |
XNQIOISZPFVUFG-RXMQYKEDSA-N
|
|||
CAS Number |
CAS 75614-87-8
|
|||
PubChem Compound ID | ||||
PubChem Substance ID |
7978667, 11113570, 15146561, 16093057, 26751775, 46232384, 47434820, 47515539, 47885613, 48105152, 48179687, 48334726, 48404445, 49846718, 50065157, 50075028, 50104462, 57348301, 76714569, 90340819, 103173299, 103942877, 113435493, 117393350, 124749862, 129714812, 132626135, 134338589, 134346127, 135112540, 135650415, 135651165, 139603316, 140261834, 163425851, 164229681, 179151084, 184607645, 224300217, 226453626, 230109526, 244113949
|
|||
ChEBI ID |
CHEBI:73337
|
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Histamine H3 receptor (H3R) | Target Info | Agonist | [3], [4], [5] |
Histamine H4 receptor (H4R) | Target Info | Agonist | [5] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Reactome | Histamine receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | Monoamine Transport | |||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
---|---|---|---|---|
REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1237). | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1236). | |||
REF 3 | The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. | |||
REF 4 | Azomethine prodrugs of (R)-alpha-methylhistamine, a highly potent and selective histamine H3-receptor agonist. Curr Med Chem. 2001 Sep;8(11):1329-40. | |||
REF 5 | Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.