Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03TNT
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| Former ID |
DNC002614
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| Drug Name |
(11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE
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| Synonyms |
Corticosterone; CORTICOSTERONE; 50-22-6; 17-Deoxycortisol; Reichstein's substance H; Kendall's compound B; Corticosteron; 11beta,21-Dihydroxyprogesterone; Compound B; Reichstein's B; 11-Hydroxycorticoaldosterone; (11beta)-11,21-Dihydroxypregn-4-ene-3,20-dione; 11beta,21-Dihydroxy-4-pregnene-3,20-dione; 4-Pregnene-11beta,21-diol-3,20-dione; 11,21-Dihydroxyprogesterone; 11Beta,21-dihydroxypregn-4-ene-3,20-dione; 11,12-Dihydroxyprogesterone; UNII-W980KJ009P; CCRIS 6753; 11-beta,21-Dihydroxypregn-3,20-dione; CHEBI:16827; NSC9705; corticosterone
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C21H30O4
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| Canonical SMILES |
CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O
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| InChI |
1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
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| InChIKey |
OMFXVFTZEKFJBZ-HJTSIMOOSA-N
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| CAS Number |
CAS 50-22-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5219, 75084, 804393, 841767, 855741, 6435953, 7886418, 7978988, 8143631, 8153530, 10321632, 11466460, 11467580, 11486119, 17389502, 17404783, 24278302, 24856812, 24869860, 25630774, 26751495, 26758495, 29224789, 46386953, 46504547, 47275526, 47646532, 48018879, 48243330, 48318377, 48393901, 48393902, 48421980, 48424986, 49698488, 49956045, 50104040, 53777326, 53788667, 53834312, 56311825, 56312404, 56312772, 56313244, 56423132, 57322931, 57390013, 57648276, 57650717, 58685480
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| ChEBI ID |
CHEBI:16827
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2869). | |||
| REF 2 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | |||
| REF 3 | Functional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis. Gln-642 plays an important role in steroid recognition and binding. J Biol Chem. 2000Jun 23;275(25):19041-9. | |||
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