Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03UID
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| Former ID |
DNC001218
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| Drug Name |
RJR-2403
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| Synonyms |
Metanicotine; Rivanicline; RJR-2403; Trans-metanicotine; 15585-43-0; Rivanicline [INN]; 538-79-4; (E)-Metanicotine; UNII-6H35LF645A; NSC 66331; 3-Buten-1-amine, N-methyl-4-(3-pyridinyl)-; TC-2403; AI3-18211; CHEMBL132966; 6H35LF645A; (3E)-N-Methyl-4-(pyridin-3-yl)but-3-en-1-amine; But-3-en-1-amine, N-methyl-4-(pyridin-3-yl)-, (E)-; Pyridine, 3-(4-(methylamino)-1-butenyl)-; (E)-N-methyl-4-pyridin-3-ylbut-3-en-1-amine; (3E)-N-methyl-4-(3-pyridinyl)-3-buten-1-amine
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| Drug Type |
Small molecular drug
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| Indication | Cognitive impairment [ICD-11: 6D71; ICD-10: F06.7] | Discontinued in Phase 2 | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C10H14N2
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| Canonical SMILES |
CNCCC=CC1=CN=CC=C1
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| InChI |
1S/C10H14N2/c1-11-7-3-2-5-10-6-4-8-12-9-10/h2,4-6,8-9,11H,3,7H2,1H3/b5-2+
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| InChIKey |
JUOSGGQXEBBCJB-GORDUTHDSA-N
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| CAS Number |
CAS 15585-43-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
111416, 609860, 7978539, 11056174, 15171050, 26752048, 39340703, 50032750, 50064512, 53091354, 57359305, 103129209, 103369533, 103957123, 114154935, 117521745, 132556611, 134224167, 135029806, 135253531, 136352882, 137001273, 137010080, 143156490, 152258469, 152344535, 160647304, 164229888, 164762647, 164780426, 175427044, 178100820, 198984640, 198992135, 223807308, 226492038, 226492039, 252479545
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nicotinic acetylcholine receptor (nAChR) | Target Info | Agonist | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3994). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007149) | |||
| REF 3 | The therapeutic potential of nicotinic acetylcholine receptor agonists for pain control. Expert Opin Investig Drugs. 2001 Oct;10(10):1819-30. | |||
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