Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03YCW
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| Former ID |
DNC009179
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| Drug Name |
4'-Demethyl-epipodophyllotoxin
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| Synonyms |
4'-Demethylepipodophyllotoxin; 6559-91-7; 4'-DMEP; 4-Demethylepipodophyllotoxin; UNII-X0S6I23X6L; (-)-4'-Demethylepipodophyllotoxin; BRN 1358259; X0S6I23X6L; CHEBI:74422; C21H20O8; (5R,5aR,8aR,9S)-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one; (5s,5ar,8ar,9r)-9-(3,5-Dimethoxy-4-Oxidanyl-Phenyl)-5-Oxidanyl-5a,6,8a,9-Tetrahydro-5h-[2]benzofuro[6,5-F][1,3]benzodioxol-8-One; Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one, 5,8,8a,9-tetrahydro-9-hydrox
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C21H20O8
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| Canonical SMILES |
COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O
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| InChI |
1S/C21H20O8/c1-25-15-3-9(4-16(26-2)20(15)23)17-10-5-13-14(29-8-28-13)6-11(10)19(22)12-7-27-21(24)18(12)17/h3-6,12,17-19,22-23H,7-8H2,1-2H3/t12-,17+,18-,19+/m0/s1
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| InChIKey |
YVCVYCSAAZQOJI-JHQYFNNDSA-N
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| CAS Number |
CAS 6559-91-7
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:74422
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase II (TOP2) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Antitumor agents, 107. New cytotoxic 4-alkylamino analogues of 4'-demethyl-epipodophyllotoxin as inhibitors of human DNA topoisomerase II. J Nat Prod. 1989 May-Jun;52(3):606-13. | |||
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