Drug Information
Drug General Information | Top | |||
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Drug ID |
D03YHZ
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Former ID |
DNC009639
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Drug Name |
6-Isoquinolin-4-yl-3,4-dihydroquinolin-2(1H)-one
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Synonyms |
CHEMBL456390; 6-Isoquinolin-4-yl-3,4-dihydroquinolin-2(1H)-one; SCHEMBL1120250; BDBM50273813
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C18H14N2O
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Canonical SMILES |
C1CC(=O)NC2=C1C=C(C=C2)C3=CN=CC4=CC=CC=C43
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InChI |
1S/C18H14N2O/c21-18-8-6-13-9-12(5-7-17(13)20-18)16-11-19-10-14-3-1-2-4-15(14)16/h1-5,7,9-11H,6,8H2,(H,20,21)
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InChIKey |
TVVPAZUMRVMIFM-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Steroid 11-beta-hydroxylase (CYP11B1) | Target Info | Inhibitor | [1] |
BioCyc | Superpathway of steroid hormone biosynthesis | |||
Glucocorticoid biosynthesis | ||||
Mineralocorticoid biosynthesis | ||||
KEGG Pathway | Steroid hormone biosynthesis | |||
Metabolic pathways | ||||
Pathwhiz Pathway | Steroidogenesis | |||
Reactome | Glucocorticoid biosynthesis | |||
Endogenous sterols | ||||
WikiPathways | Metapathway biotransformation | |||
Oxidation by Cytochrome P450 | ||||
Metabolism of steroid hormones and vitamin D | ||||
Corticotropin-releasing hormone |
References | Top | |||
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REF 1 | In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. |
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