Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D03ZKE
|
|||
Former ID |
DCL000759
|
|||
Drug Name |
CS-003
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Chronic obstructive pulmonary disease [ICD-11: CA22; ICD-10: J44, J44.9] | Discontinued in Phase 2 | [1] | |
Company |
Sankyo
|
|||
Structure |
Download2D MOL
|
|||
Formula |
C34H39Cl3N2O6S
|
|||
Canonical SMILES |
COC1=CC(=CC(=C1OC)OC)C(=O)N2CCOC(C2)(CCN3CCC4(CC3)C5=CC=CC=C5CS4=O)C6=CC(=C(C=C6)Cl)Cl.Cl
|
|||
InChI |
1S/C34H38Cl2N2O6S.ClH/c1-41-29-18-24(19-30(42-2)31(29)43-3)32(39)38-16-17-44-33(22-38,25-8-9-27(35)28(36)20-25)10-13-37-14-11-34(12-15-37)26-7-5-4-6-23(26)21-45(34)40;/h4-9,18-20H,10-17,21-22H2,1-3H3;1H/t33-,45-;/m0./s1
|
|||
InChIKey |
IHDDYKNRVLPVEV-FFKPOUSOSA-N
|
|||
PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Neuromedin-K receptor (TACR3) | Target Info | Antagonist | [1] |
Substance-K receptor (TACR2) | Target Info | Antagonist | [1] | |
Substance-P receptor (TACR1) | Target Info | Antagonist | [1] | |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Measles | ||||
Panther Pathway | CCKR signaling map ST | |||
Reactome | G alpha (q) signalling events | |||
WikiPathways | Gastrin-CREB signalling pathway via PKC and MAPK | |||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
SIDS Susceptibility Pathways | ||||
Spinal Cord Injury |
References | Top | |||
---|---|---|---|---|
REF 1 | Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.