Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D03ZVD
|
|||
Former ID |
DIB003405
|
|||
Drug Name |
KW-4490
|
|||
Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Discontinued in Phase 2 | [1] | |
Company |
Kyowa Hakko Kogyo Co Ltd
|
|||
Structure |
Download2D MOL |
|||
Formula |
C17H19NO5
|
|||
Canonical SMILES |
COC1=C2C(=C(C=C1)C3(CCC(CC3)C(=O)O)C#N)OCCO2
|
|||
InChI |
1S/C17H19NO5/c1-21-13-3-2-12(14-15(13)23-9-8-22-14)17(10-18)6-4-11(5-7-17)16(19)20/h2-3,11H,4-9H2,1H3,(H,19,20)
|
|||
InChIKey |
SBCKAEJLDHJBNZ-UHFFFAOYSA-N
|
|||
PubChem Compound ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Phosphodiesterase 4A (PDE4A) | Target Info | Inhibitor | [2] |
Phosphodiesterase 4B (PDE4B) | Target Info | Inhibitor | [2] | |
Phosphodiesterase 4D (PDE4D) | Target Info | Inhibitor | [2] | |
KEGG Pathway | Purine metabolism | |||
cAMP signaling pathway | ||||
Morphine addiction | ||||
NetPath Pathway | IL5 Signaling Pathway | |||
IL2 Signaling Pathway | ||||
Pathwhiz Pathway | Purine Metabolism | |||
Reactome | DARPP-32 events | |||
G alpha (s) signalling events | ||||
WikiPathways | G Protein Signaling Pathways | |||
Myometrial Relaxation and Contraction Pathways | ||||
TSH signaling pathway | ||||
Nuclear Receptors Meta-Pathway | ||||
Opioid Signalling |
References | Top | |||
---|---|---|---|---|
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017153) | |||
REF 2 | Pharmacokinetics and metabolism of KW-4490, a selective phosphodiesterase 4 inhibitor: difference in excretion of KW-4490 and acylglucuronide metabolites between rats and cynomolgus monkeys. Xenobiotica. 2008 May;38(5):511-26. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.