Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04DUF
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| Drug Name |
Phenylsulfonyl derivative 2
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| Synonyms |
PMID29334795-Compound-47
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| Drug Type |
Small molecular drug
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| Indication | Central nervous system disease [ICD-11: 8A04-8D87] | Patented | [1] | |
| Company |
OXYGEN HEALTHCARE RESEARCH PVT. LTD SHIRSATH, Vikas S. PATEL, Shailesh M SHETH, Nehal M. SINGH, Jitendra K. PATIL, Pawan D. PAWAR, Anil D. MOTIVARAS, Jitendra D
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| Structure |
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Download2D MOL |
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| Formula |
C23H27N3O2S
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| Canonical SMILES |
C1CCN(C1)CCCC(=O)NC2=CC3=C(C=C2)SCCN3C(=O)C4=CC=CC=C4
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| InChI |
1S/C23H27N3O2S/c27-22(9-6-14-25-12-4-5-13-25)24-19-10-11-21-20(17-19)26(15-16-29-21)23(28)18-7-2-1-3-8-18/h1-3,7-8,10-11,17H,4-6,9,12-16H2,(H,24,27)
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| InChIKey |
NSMKNQYJLDRTTI-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H3 receptor (H3R) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Histamine H3 receptor (H3R) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine Transport | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. | |||
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